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The Senate is comprised of 100 seats total. The Republican Party currently controls a majority of these seats. The current breakdown is 51 Republican seats and 49 Democratic seats (including two Independents). Of the 100 seats, 35 will be up for election in November.
In order for the Senate to flip from Republican control to Democratic control, the Democratic Party would need to gain 2 seats.
Of the 35 seats that are up for grabs in November, the Republican Party currently holds 9 seats and the Democratic Party currently holds 26 seats. Of the 9 seats that the Republican Party currently holds, 5 seats are either safe or lean in favor of Republican candidates, while 4 seats are considered toss ups. Of the 26 seats that the Democrats are defending, 22 seats are either safe or lean in favor of Democratic candidates, while the remaining 4 seats are considered toss ups.
Asterisk Indicates Incumbent
Sources: Cook Political Report, RealClear Politics